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Comparison of t-Boc and Fmoc solid-phase peptide synthesis

At the end of the synthesis the Ser or Thr will be regenerated in the final TFA cleavage step.

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Other Syntheses of Boc-Protected Amino Groups

A special paragraph will be dedicated to the problems caused by peptide aggregation in the course of the synthesis. This phenomenon is a major cause of trouble as it is difficult to predict, is sequence dependent and no universal solution has been found up to now.

This modified amino acid is obtained when synthesizing peptides with C-terminal Cys.

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The general process for the solid phase synthesis of ..

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method for t-Boc synthesis as HF is ..

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Boc Protection Mechanism (Boc2O)

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