Comparison of t-Boc and Fmoc solid-phase peptide synthesis
At the end of the synthesis the Ser or Thr will be regenerated in the final TFA cleavage step.
Other Syntheses of Boc-Protected Amino Groups
A special paragraph will be dedicated to the problems caused by peptide aggregation in the course of the synthesis. This phenomenon is a major cause of trouble as it is difficult to predict, is sequence dependent and no universal solution has been found up to now.
"Convenient syntheses of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics."
Overview of Solid Phase Peptide Synthesis (SPPS)
"Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterization of an aminotransferase involved in the pathway to 2-deoxystreptamine."
Huang, Y.-Q.; Zhou, X.-Y.; Shen, Z.-L.; Liu, G.-X.; Yu, J.-Q.; Sun, W.-Y.
"Synthesis and crystal stryctyre if a novel Ag(I) 1-D coordination polymer with a 2-oxazoolinyl-containing tripodal ligand"
The general process for the solid phase synthesis of ..
Jian He, Toshihiko Shigenari and Jin-Quan Yu
"Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp3)-H Bonds: Synthesis of b-Amino Acids"
Youqian Deng, Wei Gong, Jian He and Jin-Quan Yu
"Ligand-Enabled Triple C-H Activation Reactions: One-Pot Synthesis of Diverse 4-Aryl-2-quinolinones from Propionamides"
for instance in solid phase peptide synthesis
Synthesis of Spirotryprostatin-B ..
Jin-Quan Yu "Directed C-H Activation Reactions of Synthetically Versatile Substrates: A Journey to Practicality" Adv.
Overview of Peptide Synthesis - AnaSpec
Baran "C-H Functionalization Logic Enables Synthesis of (+)-Hongoquercin A and Related Compounds" Angew.
Boc Peptide Synthesis - Techniques in Protein …
Wasa, M.; Yu, J.-Q. "Synthesis of beta, gamma and delta-Lactams via Pd(II)-Catalyzed C-H Activation Reactions" J.
method for t-Boc synthesis as HF is ..
Vora, Xi-Sheng Wang, and Jin-Quan Yu
"Pd(II)-Catalyzed Enantioselective C-H Activation/C-O Bond Formation: Synthesis of Chiral Benzofuranones"
Protecting Groups List - The Organic Synthesis Database
Mengchun Ye, Andrew Edmunds, James Morris, David Sale, Yejia Zhang and Jin-Quan Yu
"A Robust Protocol for Pd(II)-catalyzed C-3 Arylation of (1H)Indazoles and Pyrazoles: Total Synthesis of Nigellidine Hydrobromide"
Synthesis of hydantoins - Organic Chemistry Portal
Hengbin Wang , Gang Li , Keary M Engle , Jin-Quan Yu , and Huw Madoc Lynn Davies
"Sequential C-H Functionalization Reactions for the Enantioselective Synthesis of Highly Functionalized 2,3-Dihydrofurans"
Asymmetric Total Syntheses of Colchicine, β …
Laforteza, and Jin-Quan Yu
"Synthesis of Indolines via Pd(II)-Catalyzed Amination of C-H Bonds Using PhI(OAc)2 as the Bystanding Oxidant"
Solid-phase synthesis - Wikipedia
Engle, Jin-Quan Yu
"Heterocycle Formation via Palladium-Catalyzed C-H Functionalization"
Synthesis 2012, 44, 1778.
Boc Protection Mechanism (Boc2O)
Rheingold and Jin-Quan Yu
"Pd-catalyzed Enantioselective C-H Iodination: Asymmetric Synthesis of Chiral Diarylmethylamines"
Boc-Protected Amino Groups - Organic chemistry
Spangler, Anna Homs and Jin-Quan Yu
"Ligand-Controlled C(sp3)-H Arylation and Olefination in Syntheses of Unnatural Chiral a-Amino Acids"
Science 2014, 343, 1216.
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