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The Pharmaceutical Century - 1940s - UAH

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He died in , . The principal industrial process for the artificial synthesis of still bears his name. Reichstein was the longest-lived Nobel laureate at the time of his death, but was surpassed in 2008 by .

The role of American Nobel Prize Winners in the history of the United States of America.

As an alternative to the Reichstein-Grussner process, the Advanced Technology Program of the National Institute of Standards and Technology has supported an effort by Genencor, Eastman Chemical, MicroGenomics Company, Argonne National Laboratory, and Electrosynthesis Company to develop continuous biocatalytic systems for making ascorbic acid. The focus of this review is a 2000 Genencor patent application for the preparation of 2-keto-L-gulonic acid, an important ascorbic acid intermediate, by biocatalytic conversion of glucose. We examine the economics and technical issues for a new grass-roots 20 million lb/yr (9,000 t/yr) ascorbic acid facility based on this biocatalysis technology.

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The synthesis of L-ascorbic acid developed in 1934 by Reichstein and Grussner has remained a cornerstone for the commercial production of vitamin C

Apart from hormone research, Reichstein is also known for his synthesis of vitamin C, a feat achieved about the same time (1933) in England by Sir Walter N. Haworth and coworkers. In the latter part of his career, Reichstein studied plant glycosides, chemicals that can be used in the development of therapeutic drugs. He was awarded the Copley Medal of the British Royal Society in 1968.


Tadeus Reichstein
(1897 - 1996)



Swiss chemist who, with Philip S. Hench and Edward C. Kendall, received the Nobel Prize for Physiology or Medicine in 1950 for his discoveries concerning hormones of the adrenal cortex.
Reichstein was educated in Zurich and held posts in the department of organic chemistry at the Federal Institute of Technology, Zurich, from 1930. From 1946 to 1967 he was professor of organic chemistry at the University of Basel. He received the Nobel Prize for research carried out independently on the steroid hormones produced by the adrenal cortex, the outer layer of the adrenal gland. Reichstein and his colleagues isolated about 29 hormones and determined their structure and chemical composition. One of the hormones they isolated, cortisone, was later discovered to be an anti-inflammatory agent useful in the treatment of arthritis. Reichstein was also involved in developing methods to synthesize the hormones he had discovered, among them cortisone and desoxycorticosterone, which was used for many years to treat Addison's disease.

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The word Reichstein has a web popularity of 721000 pages. What means Reichstein? The meaning of Reichstein is unknown. Web synthesis about this name:

The world's two largest producers of ascorbic acid are BASF and Roche. DSM will soon acquire Roche's vitamins business. Chinese producers are also a significant source of ascorbic acid in world markets. The synthesis of L-ascorbic acid developed in 1934 by Reichstein and Grussner has remained a cornerstone for the commercial production of vitamin C. Almost all industrial processes for ascorbic acid are derived from the Reichstein and Grussner process. The process is a complicated route that begins with D-glucose and has six major steps.

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