The former incorrect name sec-pentylthiophene has been changed.
Keywords: Thiophene, 2-chloro-N-arylacetamide, diazonium salt, azo disperse dyes, polyester fibers, fastness properties
2-pentyl thiophene, 4861-58-9 - The Good Scents …
Yield: 71%, m.p.: 203-205oC (ethanol). IR (KBr, cm-1): 3389, 3277, 3166 (NH2, NH), 1660 (C=O), 1588 (C=N), 1525, 1371, 1104, 872 (NCS), 1231, 1043 (C-S-C). 1H-NMR (DMSO-d6, ppm): 2.26 (s, 3H, phenyl CH3), 2.43 (s, 3H, CH3), 6.42 (s, 1H, thiazoline-C3-H), 6.91-7.55 (m, 9H, phenyl & Ar-H), 7.73 (s, 2H, thiophene-C5-NH2, D2O exchangeable), 7.86 (s, 2H, CONH2, D2O exchangeable), 10.50 (s, 1H, CONH, D2O exchangeable). Anal. Calcd. (%) for C23H21N5O2S2 (463.58): C, 59.59; H, 4.57; N, 15.11. Found: C, 59.72; H, 4.55; N, 15.32.
Yield: 73%, m.p.: 195-7oC (ethanol). IR (KBr, cm-1): 3378, 3276, 3170 (NH2, NH), 1654 (C=O), 1583 (C=N), 1524, 1372, 1098, 868 (NCS), 1231, 1039 (C-S-C). 1H-NMR (DMSO-d6, ppm): 2.43 (s, 3H, CH3), 6.37 (s, 1H, thiazoline-C3-H), 6.95-7.53 (m, 10H, 2 phenyl-H), 7.76 (s, 2H, thiophene-C5-NH2, D2O exchangeable), 7.96 (s, 2H, CONH2, D2O exchangeable), 10.53 (s, 1H, CONH, D2O exchangeable). Anal. Calcd. (%) for C22H19N5O2S2 (449.55): C, 58.78; H, 4.26; N, 15.58. Found: C, 58.87; H, 4.30; N, 15.73.
2-pentyl thiophene, 4861-58-9 - The Good Scents Company
The reaction of the 2-(4-oxo-4,4-dihydrothiazol-2-yl)acetonitrile 1 with cyaclopentanone (2) afforded the condensed product 3. The latter underwent a series of heterocyclizations through its reaction with different reagents. Moreover, compound 1 underwent the Gewald’s thiophene to afford compounds 15 and 17. The reaction of either hydrazine hydrate or phenylhydrazine with compound 17 gave the hydrazide derivatives 19a and 19b, respectively. The cytotoxicity of the newly synthesized products was measured towards the three cancer cell lines MCF-7, NCI-H460 and SF-268. The study showed that compounds 3, 5, 9c, 11, 13a, 13c, 17 and 19b were the most active compounds towards the three cancer cell lines.
Moreover, compound 3 was coupled with any of 4-chlorobenzenediazonium chloride 8b, 4-methoxybenzene- diazonium chloride 8c or 4-methyl benzene diazonium chloride 8d in the presence of ethanol and sodium hydroxide gave the arylhydrazone derivatives 13a-c, respectively. Compound 1 reacted with elemental sulphur and cyanoacetanilide (14) in 1,4-dioxane and the presence of triethylamine to give the ethyl 3,5-diamino-4- (4-oxo-4,5- dihydrothiazol-2-yl)thiophene-2-carboxylate 15.
In this work 3-chloro-2-chlorocarbonylbenzo[b]thiophene ..
Similarly the reaction of compound 1 with elemental sulphur and ethyl acetoacetate 16 gave the ethyl 5-ami- no-3-methyl-4-(4-oxo-4,5-dihydrothiazol-2-yl)thiophene-2-carboxylate (17). Compound 17 reacted with either hydrazinehydrate or phenylhydrazine to give the hydrazide derivatives 19a and 19b, respectively ().
We now report on the synthesis of compounds derived from benzo[b]thiophene containing oxadiazole, thiadiazole and triazole moieties, with the purpose of investigating in the future their possible antibacterial and antifungal activities.
urea, piperidine, barbituric acid, thiophene-2 ..
2-(chloromethyl)thiophene | C5H5ClS - ChemSynthesis
Synthesis of diazotized 2-(2-amino-4,5,6,7-tetrahydrobebzo[b]thiophen-3-yl)thiazol-4 (5H)-one derivatives (9a-c).
Thiophene 2-Aldehyde by Peony International. …
Buy high quality Thiophene 2-Aldehyde by Peony ..
thiophene-2-aldehyde, thiophene-2-ethanol ..
Heterocyclization of the highly versatile ethyl 2-arylhydrazono-2-phenylthiocarbamoyl acetate derivatives 2 with 2-chloro-N-aryl-acetamide reagents in the presence of sodium ethoxide furnished the corresponding 4-arylazo -3-hydroxythiophene dyes 4 and 5. These dyes were applied as disperse dyes for dyeing polyester fibers and their characteristics and fastness properties have been measured.
the first synthesis of thiophene by ..
The starting material for the synthesis of the targeted compounds is 3-chloro-2- chlorocarbonyl benzo[b]thiophene (1) which was prepared by the reaction of cinnamic acid with thionyl chloride in DMF and dry pyridine according to the reported method .
thiophene forms an azeotrope with ethanol
Further, 3-chloro-2-(N-formyl acid hydrazide)benzo[b]thiophene (4) was obtained in 70% yield when the acid hydrazide 2 was allowed to react with formic acid[,].
The Synthesis and Cytotoxicity of Novel Thiophene Derivatives ..
Three series of pyrazole, thiazole and 1,3,4-oxadiazole, derivatives were synthesized starting from 5-amino-4-(hydrazinocarbonyl)-3-methylthiophene-2-carboxamide (2).
New Azo Heterocyclic Disperse Dyes with Thiophene …
Encouraged by these findings, A new series of thiophene derivatives comprising the bioactive pyrazoles, thiazoles and 1,3,4-oxadiazoles at position 4 were synthesized and biologically evaluated.
Functional use(s) - flavoring agents. Has an fruity type odor.
Yield: 62%, m.p.: 228-30oC. IR (KBr, cm-1): 3387, 3296, 3222, 3115 (NH2, NH), 1657 (C=O), 1624 (C=N), 1271, 1017 (C-S-C). 1H-NMR (DMSO-d6, ppm): 2.43 (s, 3H, CH3), 4.36 (s, 2H, NH2, D2O exchangeable), 7.61 (s, 2H, thiophene-C5-NH2, D2O exchangeable), 8.07 (s, 2H, CONH2, D2O exchangeable), 8.90 (s, 1H, NH, D2O exchangeable). 13C-NMR (DMSO-d6, ppm): 14.76 (CH3), 105.68 (thiophene C4), 111.44 (thiophene C2), 139.78 (thiophene C3), 163.62, 165.26 (2 C=O), 165.40 (thiophene C5). Anal. Calcd. (%) for C7H10N4O2S (214.24): C, 39.24; H, 4.70; N, 26.15. Found: C, 39.52; H, 5.12; N, 26.37.
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